A submucosal lifting agent is a medical substance used in endoscopic procedures, primarily during endoscopic mucosal resection(EMR) and endoscopic submucosal dissection (ESD). The primary aim of submucosal lifting agents is to create a separation between the mucosal and submucosal layers of the gastrointestinal tract, facilitating the visualization and dissection of lesions or tumors. This lifting effect aids in the safe and efficient removal of abnormal tissues, contributing to improved diagnostic and therapeutic outcomes in gastrointestinal endoscopy. Submucosal lifting agents play a crucial role in minimizing the risk of perforation and enhancing the precision of endoscopic interventions, making them essential tools in the field of gastroenterology.